Development of tau propagation mice model
نویسندگان
چکیده
منابع مشابه
Tau Propagation, Different Tau Phenotypes, and Prion-like Properties of Tau
Sanders et al. (2014) demonstrate in this issue of Neuron that the natively unfolded protein tau can propagate indefinitely in distinct stable strains, therefore supporting the general idea that tau has prion-like properties, with implications for Alzheimer's disease and other tauopathies.
متن کاملFormation and Propagation of Tau Oligomeric Seeds
Tau misfolding and aggregation leads to the formation of neurofibrillary tangles (NFTs), which have long been considered one of the main pathological hallmarks for numerous neurodegenerative diseases known as tauopathies, including Alzheimer's Disease (AD) and Parkinson's Disease (PD). However, recent studies completed both in vitro and in vivo suggest that intermediate forms of tau, known as t...
متن کاملTau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage
Aging has long been considered as the main risk factor for several neurodegenerative disorders including a large group of diseases known as tauopathies. Even though neurofibrillary tangles (NFTs) have been examined as the main histopathological hallmark, they do not seem to play a role as the toxic entities leading to disease. Recent studies suggest that an intermediate form of tau, prior to NF...
متن کامل'Prion-like' propagation of mouse and human tau aggregates in an inducible mouse model of tauopathy.
BACKGROUND Aggregates of the tau protein are a hallmark of Alzheimer's and several other neurodegenerative diseases. Various transgenic mouse models have been generated to study the aggregation process. Since wild-type tau is highly soluble and does not aggregate readily, most models make use of tau mutations that occur in human frontotemporal dementias and are more prone to aggregate. These mo...
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this experimental study has been conducted to test the effect of oral presentation on the development of l2 learners grammar. but this oral presentation is not merely a deductive instruction of grammatical points, in this presentation two hypotheses of krashen (input and low filter hypotheses), stevicks viewpoints on grammar explanation and correction and widdowsons opinion on limited use of l1...
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ژورنال
عنوان ژورنال: Proceedings for Annual Meeting of The Japanese Pharmacological Society
سال: 2019
ISSN: 2435-4953
DOI: 10.1254/jpssuppl.92.0_3-o-10